At-Home COMT Gene Test: Simple Cheek Swab - Gene Food

COMT/MTHFR Status + Gene Food Diet Type

$424Kit plus Health Intelligence. One-time price.
1
Included with Health Intelligence

Learn your status for important COMT SNPs which play a role in dopamine and methylation. The Gene Food COMT Test includes a complete methylation panel as well as a dedicated MTHFR report.

  • CLIA-Certified Lab
  • Personalized DNA insights
  • Data Never Sold

What You'll Learn

  • Tests for COMT SNPs, including rs4633 & rs4680
  • Includes full methylation panel as well as MTHFR report
  • Data is 100% confidential and secure
  • Learn your Gene Food diet type and micronutrient needs
COMT Gene Report

Learn your status for important COMT SNPs

The COMT gene encodes an enzyme called called catechol-O-methyltransferase that functions to break down dopamine after its release. This process ensures that just the right dopamine concentration binds to and activates the next neuron. If too much dopamine binds, an increase in impulsive and aggressive behavior is observed. However, if too little binds, depressive/anxious behaviors occur as a result.

COMT variants can therefore be used as molecular genetic markers associated with anxiety, pain, and stress response, however it’s important to note that these variants are common. They cannot be considered defining factors in the development of all mental states, as multiple factors have been shown to play a role.

The COMT variant that determines worrier vs. warrior status is rs4680. The SNP is defined by an amino acid substitution of methionine (Met) in place of valine (Val) at position 158 (Val158Met). Depending on your gene copy number, you could be classed as a worrier (A genotype), a warrior (G genotype), or a mix of the two (AG genotype).

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COMT Gene Report example
Illustrative report example, not your personal results.
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Find out how your body actually handles carbs

Low-carb works for some people and backfires for others. In the PREDICT-1 trial, genetics accounted for nearly half of the variation in how much blood sugar rose two hours after a meal. Our CLIA-certified test scores your carbohydrate response across multiple validated SNPs, matches you to one of 20 diet types, and turns it into a plan: the carbs that suit you, the ones to limit, and a two-week meal plan built around them.

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Frequently asked questions

The Gene Food COMT test reports on two well studies SNPs, rs4633 & rs4680. The COMT gene variant that determines worrier vs. warrior status is rs4680.

This variant plays a role in how dopamine is metabolized in the brain. In addition, Gene Food also includes rs4680 and rs4633 in our dedicated Methylation report, which comes with the Health Intelligence membership.

While the impact of the COMT gene is probably oversold in some functional medicine circles, COMT status plays an important role in dopamine metabolism as well as methylation. As we document in our popular blog post on this topic, the COMT gene encodes an enzyme called called catechol-O-methyltransferase that functions to break down dopamine after its release.

This process ensures the right dopamine concentration binds to and activates the next neuron. If too much dopamine binds, an increase in impulsive and aggressive behavior is observed. However, if too little binds, depressive/anxious behaviors occur as a result.

COMT variants can therefore be used as molecular genetic markers associated with anxiety, pain, and stress response.

This report is available with the Methylation Bundle (Health Intelligence), alongside the core reports included with your Gene Food DNA test. Current bundle pricing is shown above.

Like all our tests, the COMT report and methylation report is a simple cheek swab test. A self-addressed return envelope is included with the test kit, as are detailed instructions for taking the test. The swab sample is sent to our CLIA-certified laboratory in Houston, where the sequencing occurs.